Rhodanol synthons for fluorescent labeling and drug conjugates Conference Paper
| Authors: | Spassova, M.; Kois, P.; Watanabe, K. |
| Title: | Rhodanol synthons for fluorescent labeling and drug conjugates |
| Conference Title: | 10th Symposium on the Chemistry of Nucleic Acid Components |
| Abstract: | The synthesis of Rhodanol derivatives Ib-lj is described. Rhodamine 123 was reduced to the corresponding alcohol and after acetylation of the amino functionalities, the protected Rhodanol was further derivatized by alkylation with oxirane, chloromethyloxirane and 2-acetoxyethoxymethylchloride. The coupling of some synthons to FU and FUrd at different conditions was studied. Synthons lat ii, and If were converted to phosphoramidities and used for 5'-labeling of oligonucleotides as a final step in solid-phase synthesis on automated DNA synthesizer. |
| Keywords: | dye; oligonucleotides |
| Journal Title | Collection of Czechoslovak Chemical Communications |
| Volume: | 61 |
| Conference Dates: | 1996 Sep 1-7 |
| Conference Location: | Třešť, Czech Republic |
| ISBN: | 0010-0765 |
| Publisher: | Inst Organic Chem and Biochem |
| Date Published: | 1996-01-01 |
| Start Page: | S290 |
| End Page: | S293 |
| Language: | English |
| ACCESSION: | WOS:A1996VL26600086 |
| PROVIDER: | wos |
| DOI: | 10.1135/cccc1996s290 |
| Notes: | Proceedings Paper -- Special Issue -- Source: Wos |
