Botulinum neurotoxins: Mechanism of action and therapeutic applications Journal Article

  


Authors: Montecucco, C.; Schiavo, G.; Tugnoli, V.; de Grandis, D.
Article Title: Botulinum neurotoxins: Mechanism of action and therapeutic applications
Abstract: Recent studies have led to the discovery of the molecular lesions in motor neurons caused by botulinum neurotoxins. These neurotoxins are metalloproteinases that enter the cytosol and very specifically cleave protein components of the neuroexocytosis apparatus. Consequently, acetylcholine cannot be released and the muscle is paralysed. For this reason, botulinum neurotoxins are increasingly being used to treat a variety of conditions where a functional paralysis of neuromuscular junctions is useful as therapy.
Keywords: metabolism; classification; protein binding; drug effect; chemistry; models, molecular; chemical structure; metalloproteinase; synapses; synapse; botulinum toxin; botulinum toxins; muscle contraction; metalloendopeptidases; humans; human; article; neurotoxin; acetylcholine; neurotoxins; botulism; clostridium botulinum
Journal Title: Molecular Medicine Today
Volume: 2
Issue: 10
ISSN: 1357-4310
Publisher: Elsevier Science, Inc.  
Date Published: 1996-10-01
Start Page: 418
End Page: 424
Language: English
DOI: 10.1016/1357-4310(96)84845-3
PUBMED: 8897436
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030256824&doi=10.1016%2f1357-4310%2896%2984845-3&partnerID=40&md5=e8ef04be3c247c5c1a6c78f3b0854e95
Notes: Review -- Export Date: 22 November 2017 -- Source: Scopus
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