Genomic analysis reveals distinct subtypes in two rare cases of primary ovarian lymphoma Journal Article


Authors: Khattar, P.; Bedi, P.; Gonzalez, M.; Zhong, M.; Yin, C.; Huang, W.; Islam, H. K.; Fallon, J. T.
Article Title: Genomic analysis reveals distinct subtypes in two rare cases of primary ovarian lymphoma
Abstract: Primary (localized) non-Hodgkin lymphoma (NHL) of the ovary is extremely rare; only a few cases have been reported in the literature. We report two cases of primary ovarian lymphoma (POL), one involving bilateral ovaries in a 15-year-old girl and other involving one ovary in a 5-year-old girl. This report describes detailed clinical, histopathological, and imaging findings, along with the review of literature of primary diffuse large B-cell lymphoma (DLBCL) arising from an ovary. In addition, we describe findings of targeted capture panel sequencing on both tumors and identify the major genetic mutations that are recurrently mutated in pan-cancers. Compared to the genomic mutation features of major subtypes of DLBCL, we distinguish that each POL belongs to distinctive subtypes, GCB (germinal center B-cell subtype) DLBCL and ABC (activated B-cell subtype) DLBCL, respectively. The findings from the genomic analysis may help to understand the pathogenesis of POL and to guide potential targeted therapy in the future. © 2018 Elsevier GmbH
Keywords: adolescent; child; clinical article; gene mutation; somatic mutation; clinical feature; case report; hypertension; nuclear magnetic resonance imaging; lymph node dissection; salpingooophorectomy; gene; tumor volume; bleeding; genetic variation; cell population; ultrasound; b lymphocyte; abdominal pain; fever; homozygosity; transcription regulation; bone marrow biopsy; heterozygosity; lymphoma; lactate dehydrogenase; ca 125 antigen; vhl gene; cyclin d1; germ cell tumor; lactate dehydrogenase blood level; lymphadenopathy; cd19 antigen; chorionic gonadotropin beta subunit; dysuria; alpha fetoprotein; hydronephrosis; abdominal distension; uterus tumor; asxl1 gene; ezh2 gene; atm gene; bap1 gene; dysgerminoma; smarca4 gene; ovary disease; hla a gene; flt3 gene; human; female; article; cyld gene; ptch1 gene; myd88 gene; cic gene; notch1 gene; csf3r gene; kdr gene; map3k1 gene; ovarian lymphoma
Journal Title: Pathology Research and Practice
Volume: 214
Issue: 4
ISSN: 0344-0338
Publisher: Elsevier Inc.  
Date Published: 2018-04-01
Start Page: 593
End Page: 598
Language: English
DOI: 10.1016/j.prp.2017.12.017
PROVIDER: scopus
PUBMED: 29519565
DOI/URL:
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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