Diffuse large B-cell lymphomas with plasmablastic differentiation Journal Article
| Author: | Teruya-Feldstein, J. |
| Article Title: | Diffuse large B-cell lymphomas with plasmablastic differentiation |
| Abstract: | Recent evidence suggests that diffuse large B-cell lymphoma (DLBCL) with plasmablastic differentiation represents a clinically heterogeneous spectrum with different clinicopathologic characteristics representing distinct entities. Subtypes of DLBCL with plasmablastic features and terminal B-cell differentiation include plasmablastic lymphoma (PBL) of oral mucosa type; PBL with plasmacytic differentiation; primary effusion lymphoma (PEL); KSHV-positive solid lymphoma/extracavitary PEL/HHV-8 associated DLBCL; and DLBCL expressing ALK. In contrast, PBL associated with multicentric Castleman disease, DLBCL with secretory differentiation, pyothorax-associated lymphoma, and atypical Burkitt lymphoma with plasmacytoid differentiation have morphologic appearances of plasma cell differentiation but maintain a mature B-cell (CD20 positive) phenotype. These tumors as well as extramedullary plasmablastic tumors secondary to multiple myeloma or plasmacytomas are included in the differential diagnosis. In this review, we discuss recently described clinicopathologic insights, case observations, and recently reported molecules involved in terminal B-cell or plasma cell differentiation and their possible roles in disease pathogenesis. Copyright © 2005 by Current Science Inc. |
| Keywords: | vasculotropin; adult; middle aged; clinical feature; review; doxorubicin; cytarabine; methotrexate; neoplasms; cell proliferation; phenotype; cell structure; disease association; multiple myeloma; cell maturation; etoposide; differential diagnosis; interleukin 10; tumor differentiation; cyclophosphamide; vincristine; plasmacytoma; cell differentiation; ifosfamide; carcinogenesis; b-lymphocytes; b cell lymphoma; lymphocyte differentiation; plasma cell; lymphoma, b-cell; cd20 antigen; antigens, cd20; lymphoma; interleukin 6; protein bcl 6; large cell lymphoma; mucin 1; cancer classification; hermes antigen; mouth mucosa; empyema, pleural; burkitt lymphoma; human herpesvirus 8; clinical observation; interferon regulatory factor 4; tissue inhibitor of metalloproteinase 1; common acute lymphoblastic leukemia antigen; syndecan 1; pleura empyema; primary effusion lymphoma; angiofollicular lymph node hyperplasia; giant lymph node hyperplasia; plasmablastic lymphoma; lymphoma, large-cell; granzyme a; aquaporin 3; transcription factor pax5 |
| Journal Title: | Current Oncology Reports |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2005-09-01 |
| Start Page: | 357 |
| End Page: | 363 |
| Language: | English |
| PUBMED: | 16091196 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 21" - "Export Date: 24 October 2012" - "CODEN: CORUA" - "Source: Scopus" |
