Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant Journal Article


Authors: Williams, R. M.; Lee, C.; Galassi, T. V.; Harvey, J. D.; Leicher, R.; Sirenko, M.; Dorso, M. A.; Shah, J.; Olvera, N.; Dao, F.; Levine, D. A.; Heller, D. A.
Article Title: Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant
Abstract: Patients with high-grade serous ovarian carcinoma (HGSC) exhibit poor 5-year survival rates, which may be significantly improved by early-stage detection. The U.S. Food and Drug Administration-approved biomarkers for HGSC-CA-125 (cancer antigen 125) and HE4 (human epididymis protein 4)-do not generally appear at detectable levels in the serum until advanced stages of the disease. An implantable device placed proximal to disease sites, such as in or near the fallopian tube, ovary, uterine cavity, or peritoneal cavity, may constitute a feasible strategy to improve detection of HGSC. We engineered a prototype optical sensor composed of an antibody-functionalized carbon nanotube complex, which responds quantitatively to HE4 via modulation of the nanotube optical bandgap. The complexes measured HE4 with nanomolar sensitivity to differentiate disease from benign patient biofluids. The sensors were implanted into four models of ovarian cancer, within a semipermeable membrane, enabling the optical detection of HE4 within the live animals. We present the first in vivo optical nanosensor capable of noninvasive cancer biomarker detection in orthotopic models of disease. © 2018 The Authors.
Keywords: biomarkers; food and drug administration; diseases; peritoneal cavity; carbon nanotubes; implants (surgical); nanosensors; functionalized carbon nanotubes; yarn; optical nanosensors; cancer biomarker detections; implantable devices; nanomolar sensitivity; semi-permeable membranes
Journal Title: Science Advances
Volume: 4
Issue: 4
ISSN: 2375-2548
Publisher: Amer Assoc Advancement Science  
Date Published: 2018-04-01
Start Page: eaaq1090
Language: English
DOI: 10.1126/sciadv.aaq1090
PROVIDER: scopus
PMCID: PMC5906074
PUBMED: 29675469
DOI/URL:
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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MSK Authors
  1. Daniel Alan Heller
    60 Heller
  2. Janki Kalpesh Shah
    17 Shah
  3. Thomas Vito Galassi
    12 Galassi
  4. Jackson D Harvey
    11 Harvey
  5. Madeline Anne Dorso
    2 Dorso
  6. Christopher Adam Lee
    2 Lee