Synapse - Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations

Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations Journal Article

Authors:	Sia, T. Y.; Yaari, Z.; Feiner, R.; Smith, E.; Da Cruz Paula, A.; Selenica, P.; Doddi, S.; Chi, D. S.; Abu-Rustum, N. R.; Levine, D. A.; Weigelt, B.; Fleisher, M.; Ramanathan, L. V.; Heller, D. A.; Long Roche, K.
Article Title:	Uterine washings as a novel method for early detection of ovarian cancer: Trials and tribulations
Abstract:	Given the tubal origin of high-grade serous ovarian cancer (HGSC), we sought to investigate intrauterine lavage (IUL) as a novel method of biomarker detection. IUL and serum samples were collected from patients with HGSC or benign pathology. Although CA-125 and HE4 concentrations were significantly higher in IUL samples compared to serum, they were similar between IUL samples from patients with HGSC vs benign conditions. In contrast, CA-125 and HE4 serum concentrations differed between HGSC and benign pathology (P =.002 for both). IUL and tumor samples from patients with HGSC were subjected to targeted panel sequencing and droplet digital PCR (ddPCR). Tumor mutations were found in 75 % of matched IUL samples. Serum CA-125 and HE4 biomarker levels allowed for better differentiation of HGSC and benign pathology compared to IUL samples. We believe using IUL for early detection of HGSC requires optimization, and current strategies should focus on prevention until early detection strategies improve. © 2024 The Authors
Keywords:	ovarian cancer; early detection; intrauterine lavage
Journal Title:	Gynecologic Oncology Reports
Volume:	51
ISSN:	2352-5789
Publisher:	Elsevier B.V.
Date Published:	2024-02-01
Start Page:	101330
Language:	English
DOI:	10.1016/j.gore.2024.101330
PROVIDER:	scopus
PMCID:	PMC10865230
PUBMED:	38356691
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85185501219&doi=10.1016%2fj.gore.2024.101330&partnerID=40&md5=848b44e74c04e34bdc75ad3c0b7e2a8f
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Kara Long Roche -- Source: Scopus