Liquid biopsy in the diagnosis of HPV DNA in breast lesions Journal Article

  


Authors: De Carolis, S.; Pellegrini, A.; Santini, D.; Ceccarelli, C.; De Leo, A.; Alessandrini, F.; Arienti, C.; Pignatta, S.; Tesei, A.; Mantovani, V.; Zamagni, C.; Taffurelli, M.; Sansone, P.; Bonafé, M.; Cricca, M.
Article Title: Liquid biopsy in the diagnosis of HPV DNA in breast lesions
Abstract: Aim: HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens. Materials & methods: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types. Results: We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas.We also show the presence of HPV DNA in the serum-derived extracellular vesicles. Conclusion: Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology. © 2017 Monica Cricca et al.
Keywords: breast; liquid biopsy; hpv dna
Journal Title: Future Microbiology
Volume: 13
Issue: 2
ISSN: 1746-0913
Publisher: Future Medicine  
Date Published: 2018-02-01
Start Page: 187
End Page: 194
Language: English
DOI: 10.2217/fmb-2017-0145
PROVIDER: scopus
PUBMED: 28975808
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044401209&doi=10.2217%2ffmb-2017-0145&partnerID=40&md5=425ddfcdc173b491750d21bad2977d1f
Notes: Article -- Export Date: 1 May 2018 -- Source: Scopus
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  1. Pasquale Sansone
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