Tumor extracellular vesicles impede interferon alert responses Editorial
| Authors: | Kenific, C. M.; Wang, G.; Lyden, D. |
| Title: | Tumor extracellular vesicles impede interferon alert responses |
| Abstract: | Tumor-derived extracellular vesicles promote metastasis by inducing functional changes in cells at pre-metastatic sites conducive for tumor cell colonization. In this issue of Cancer Cell, Ortiz and colleagues show that type I interferon regulates extracellular vesicle uptake and that modulating this pathway holds promise for treating metastasis. © 2018 Elsevier Inc. Tumor-derived extracellular vesicles promote metastasis by inducing functional changes in cells at pre-metastatic sites conducive for tumor cell colonization. In this issue of Cancer Cell, Ortiz and colleagues show that type I interferon regulates extracellular vesicle uptake and that modulating this pathway holds promise for treating metastasis. © 2018 Elsevier Inc. |
| Keywords: | cancer survival; protein expression; overall survival; interferon; nonhuman; protein function; pancreas carcinoma; lung metastasis; ubiquitination; cell membrane; tumor cell; short survey; down regulation; monocyte; host resistance; leukocyte; interferon receptor; cell surface receptor; metastatic melanoma; exosome; receptor subunit; human; priority journal |
| Journal Title: | Cancer Cell |
| Volume: | 35 |
| Issue: | 1 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2019-01-14 |
| Start Page: | 3 |
| End Page: | 5 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2018.12.006 |
| PUBMED: | 30645974 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 1 February 2019 -- Source: Scopus |
