Molecular diagnosis in breast cancer Journal Article

  


Authors: Pareja, F.; Marchiò, C.; Reis-Filho, J. S.
Article Title: Molecular diagnosis in breast cancer
Abstract: Breast cancer is a complex and heterogeneous disease, encompassing a plethora of entities with distinct biological features and clinical behaviour. The advent of high throughput molecular methods has allowed a systematic characterization of the genomic landscape of breast cancer, revealing a profound heterogeneity in this disease. These methods are having a profound effect on the understanding of breast cancer. Some have already been incorporated in clinical practice, such as the prognostic ‘gene signatures’ that allow the tailoring of therapy in the subgroup of patients with oestrogen receptor (ER)-positive and HER2-negative breast cancer. In this review, we discuss the contribution of the main molecular methods in breast cancer research and how this information is changing our approaches to the diagnosis and management of this disease. We also address novel developments in the diagnosis and management of HER2-positive breast carcinomas and familial breast cancer. © 2018 Elsevier Ltd
Keywords: review; cancer diagnosis; breast cancer; epidermal growth factor receptor 2; prediction; in situ hybridization; cancer classification; tumor gene; breast biopsy; genetic heterogeneity; molecular diagnosis; cancer prognosis; prognosis; human; precision medicine; hereditary tumor syndrome; liquid biopsy; liquid biopsies; molecular taxonomy; prognostic signatures
Journal Title: Diagnostic Histopathology
Volume: 24
Issue: 2
ISSN: 1756-2317
Publisher: Elsevier Inc.  
Date Published: 2018-02-01
Start Page: 71
End Page: 82
Language: English
DOI: 10.1016/j.mpdhp.2018.01.001
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041602192&doi=10.1016%2fj.mpdhp.2018.01.001&partnerID=40&md5=d7b67873f62770b2e539f26114071238
Notes: Review -- Export Date: 2 April 2018 -- Source: Scopus
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MSK Authors
  1. Jorge Sergio Reis-Filho
    639 Reis-Filho
  2. Fresia Gilda Pareja Zea
    216 Pareja Zea
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