Human epidermal growth factor receptor 2-targeted PET/single- photon emission computed tomography imaging of breast cancer: Noninvasive measurement of a biomarker integral to tumor treatment and prognosis Journal Article

   

Authors:	Henry, K. E.; Ulaner, G. A.; Lewis, J. S.
Article Title:	Human epidermal growth factor receptor 2-targeted PET/single- photon emission computed tomography imaging of breast cancer: Noninvasive measurement of a biomarker integral to tumor treatment and prognosis
Abstract:	Increased human epidermal growth factor receptor 2 (HER2) expression is a hallmark of aggressive breast cancer. Imaging modalities have the potential to diagnose HER2-positive breast cancer and detect distant metastases. The heterogeneity of HER2 expression between primary and metastatic disease sites limits the value of tumor biopsies. Molecular imaging is a noninvasive tool to assess HER2-positive primary lesions and metastases. Radiolabeled antibodies, antibody fragments, and affibody molecules devise a reliable and quantitative method for detecting HER2-positive cancer using PET. HER2-targeted PET imaging is a valuable clinical tool with respect to both the care and maintenance of patients with breast cancer. © 2017 Elsevier Inc.
Keywords:	metastasis; breast cancer; imaging; pet; ct; her2; spect; radiotracers
Journal Title:	PET Clinics
Volume:	12
Issue:	3
ISSN:	1556-8598
Publisher:	Elsevier Inc.
Date Published:	2017-07-01
Start Page:	269
End Page:	288
Language:	English
DOI:	10.1016/j.cpet.2017.02.001
PROVIDER:	scopus
PUBMED:	28576166
PMCID:	PMC5545121
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020383534&doi=10.1016%2fj.cpet.2017.02.001&partnerID=40&md5=17263bdc8c9eb41b763f2797a1915e2d
Notes:	Review -- Export Date: 3 July 2017 -- Source: Scopus

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