Yolk sac macrophage progenitors traffic to the embryo during defined stages of development Journal Article
| Authors: | Stremmel, C.; Schuchert, R.; Wagner, F.; Thaler, R.; Weinberger, T.; Pick, R.; Mass, E.; Ishikawa-Ankerhold, H. C.; Margraf, A.; Hutter, S.; Vagnozzi, R.; Klapproth, S.; Frampton, J.; Yona, S.; Scheiermann, C.; Molkentin, J. D.; Jeschke, U.; Moser, M.; Sperandio, M.; Massberg, S.; Geissmann, F.; Schulz, C. |
| Article Title: | Yolk sac macrophage progenitors traffic to the embryo during defined stages of development |
| Abstract: | Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system. © 2017 The Author(s). |
| Keywords: | adult; nonhuman; cell proliferation; animal cell; mouse; animal; cytology; animals; mice, knockout; immune system; confocal microscopy; microscopy, confocal; embryo; embryonic stem cell; animal experiment; cell motion; embryo development; embryology; in vivo study; vascularization; mice, inbred c57bl; time factors; cell lineage; transgenic mouse; c57bl mouse; mice, transgenic; cardiovascular system; hematopoietic stem cells; cell movement; embryonic stem cells; embryo, mammalian; innate immunity; rodent; fetus; hematopoietic stem cell; macrophage; macrophages; intravital microscopy; blood circulation; knockout mouse; embryonic development; yolk sac; circulation; time factor; mammalian embryo; article |
| Journal Title: | Nature Communications |
| Volume: | 9 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2018-01-08 |
| Start Page: | 75 |
| Language: | English |
| DOI: | 10.1038/s41467-017-02492-2 |
| PUBMED: | 29311541 |
| PROVIDER: | scopus |
| PMCID: | PMC5758709 |
| DOI/URL: | |
| Notes: | Erratum issued, see DOI: 10.1038/s41467-018-06065-9 -- Article -- Export Date: 2 April 2018 -- Source: Scopus |
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