Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions - A systematic review Journal Article
| Authors: | Morano, W. F.; Khalili, M.; Chi, D. S.; Bowne, W. B.; Esquivel, J. |
| Article Title: | Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions - A systematic review |
| Abstract: | Background: The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use. Objective: To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies. Methods: Systematic review by PubMed search was performed using terms “Clinical trial,” “intraperitoneal chemotherapy,” and “HIPEC.” ClinicalTrials.gov and EudraCT registries were searched for active clinical trials. Eligibility included CRS/HIPEC trials investigating adult patient populations from published clinical reports and/or trials currently accruing or at completion. Results: Thirteen published trials and 57 active clinical trials were included for review. Conclusions: Published and ongoing U.S. and international clinical trials for CRS and HIPEC are defining important parameters that include improving patient selection, strategic sequences of treatment, cytoreductive strategies, chemotherapeutics, optimal hyperthermic temperature and timing, and toxicity profiles. Main barriers or limitations to trial development remain patient enrollment, trial design, and oncologic community collaboration. Overall progress is positive with increasing number of clinical trials throughout the world. Collaboration between surgeons and the wider oncologic community will be crucial to validate this important treatment strategy. © 2017 Wiley Periodicals, Inc. |
| Keywords: | cancer chemotherapy; survival rate; cisplatin; doxorubicin; clinical trials as topic; paclitaxel; cancer radiotherapy; antineoplastic agent; colorectal cancer; cytoreductive surgery; carboplatin; ovary cancer; peritoneum cancer; peritoneal neoplasms; cyclophosphamide; gamma interferon; regional perfusion; chemotherapy, cancer, regional perfusion; stomach cancer; epirubicin; meta-analysis as topic; hyperthermia, induced; peritoneum mesothelioma; peritoneum tumor; clinical trials; peritoneum pseudomyxoma; randomized controlled trial (topic); clinical trial (topic); meta analysis (topic); phase 3 clinical trial (topic); thermotherapy; peritoneal carcinomatosis; multicenter study (topic); hyperthermic intraperitoneal chemotherapy; peritoneal metastasis; perioperative intraperitoneal chemotherapy; humans; prognosis; human; priority journal; article; hipec; cytoreduction surgical procedures |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 117 |
| Issue: | 2 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2018-02-01 |
| Start Page: | 245 |
| End Page: | 259 |
| Language: | English |
| DOI: | 10.1002/jso.24813 |
| PUBMED: | 29120491 |
| PROVIDER: | scopus |
| PMCID: | PMC6692902 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 April 2018 -- Source: Scopus |
