Is there a role for hyperthermic intraperitoneal chemotherapy in ovarian cancer? Review
| Authors: | Praiss, A. M.; Moukarzel, L. A.; Zivanovic, O. |
| Review Title: | Is there a role for hyperthermic intraperitoneal chemotherapy in ovarian cancer? |
| Abstract: | Purpose of reviewOur objective is to provide a history, rationale, and review of the use of hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of ovarian cancer.Recent findingsIn the last decade, there has been an increase in the literature regarding HIPEC in the treatment of ovarian cancer. The rationale for HIPEC extends from earlier trials demonstrating improved survival using intraperitoneal chemotherapy. HIPEC provides a one-time opportunity for intraperitoneal chemotherapy at the time of cytoreduction and with the addition of hyperthermia. Cisplatin HIPEC has been demonstrated to have a survival benefit when used in the interval cytoreductive setting. In terms of safety, nephroprotection remains a key concern when administering HIPEC. Sodium thiosulfate provides nephroprotection and should be considered when performing HIPEC. Various institutions have created multidisciplinary protocols for administering HIPEC, which include operating room staff, nursing, anesthesia, pharmacy, and surgical teams.SummaryHIPEC has a role in the treatment paradigm of ovarian cancer. Currently, HIPEC is approved in the interval cytoreductive surgery setting. Further trials are needed to understand the appropriate timing, chemotherapeutic agents, and protocolization of HIPEC. © 2023 Lippincott Williams and Wilkins. All rights reserved. |
| Keywords: | multimodality cancer therapy; combined modality therapy; antineoplastic agent; ovarian cancer; cytoreductive surgery; ovarian neoplasms; antineoplastic combined chemotherapy protocols; ovary tumor; hyperthermia, induced; thermotherapy; procedures; hyperthermic intraperitoneal chemotherapy; humans; human; female |
| Journal Title: | Current Opinion in Obstetrics & Gynecology |
| Volume: | 35 |
| Issue: | 1 |
| ISSN: | 1040-872X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2023-02-01 |
| Start Page: | 21 |
| End Page: | 26 |
| Language: | English |
| DOI: | 10.1097/gco.0000000000000837 |
| PUBMED: | 36595646 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Oliver Zivanovic -- Source: Scopus |
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