Current status and future prospects of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) clinical trials in ovarian cancer Journal Article

   


Authors: Cowan, R. A.; O’Cearbhaill, R. E.; Zivanovic, O.; Chi, D. S.
Article Title: Current status and future prospects of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) clinical trials in ovarian cancer
Abstract: The natural history of advanced-stage epithelial ovarian cancer is one of clinical remission after surgery and platinum/taxane-based intravenous (IV) and/or intraperitoneal (IP) chemotherapy followed by early or late recurrence in the majority of patients. Prevention of progression and recurrence remains a major hurdle in the management of ovarian cancer. Recently, many investigators have evaluated the use of normothermic and hyperthermic intraoperative IP drug delivery as a management strategy. This is a narrative review of the current status of clinical trials of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in ovarian cancer and the future directions for this treatment strategy. The existing studies on HIPEC in patients with epithelial ovarian cancer are mostly retrospective in nature, are heterogeneous with regards to combined inclusion of primary and recurrent disease and lack unbiased data. Until data are available from evidence-based trials, it is reasonable to conclude that surgical cytoreduction and HIPEC is a rational and interesting, though still investigative, approach in the management of epithelial ovarian cancer, whose use should be employed within prospective clinical trials. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: review; cisplatin; paclitaxel; ovarian cancer; cytoreductive surgery; carboplatin; ovary cancer; ovary carcinoma; recurrent disease; surgery; oxaliplatin; clinical trials; clinical trial (topic); hyperthermic intraperitoneal chemotherapy; human; female; hyperthermic intraoperative intraperitoneal chemotherapy (hipec)
Journal Title: International Journal of Hyperthermia
Volume: 33
Issue: 5
ISSN: 0265-6736
Publisher: Taylor & Francis Group  
Date Published: 2017-01-01
Start Page: 548
End Page: 553
Language: English
DOI: 10.1080/02656736.2017.1283066
PROVIDER: scopus
PUBMED: 28092994
PMCID: PMC5776684
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021674814&doi=10.1080%2f02656736.2017.1283066&partnerID=40&md5=690c186e5a391898a8c1204f56d338f3
Notes: Review -- Export Date: 2 August 2017 -- Source: Scopus
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MSK Authors
  1. Dennis S Chi
    707 Chi
  2. Oliver Zivanovic
    291 Zivanovic
  3. Roisin Eilish O'Cearbhaill
    271 O'Cearbhaill
  4. Renee Antonette Woodburn Cowan
    32 Cowan
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