Interventional endoscopy in the diagnosis and management of pancreatic adenocarcinoma Journal Article
| Authors: | Khokhar, A. S.; Sher, A. F.; Schattner, M. |
| Article Title: | Interventional endoscopy in the diagnosis and management of pancreatic adenocarcinoma |
| Abstract: | Pancreatic cancer accounts for approximately 3% of all cancers in US, and is the fourth leading cause of mortality in both men and women. It is a silent killer due to lack of early symptoms and the majority of patients present at advanced stage at the time of initial diagnosis. Only 15-20% of patients are candidates for curative resection and even then, the 5-year survival rates range from 10-25%. Despite recent advances in the treatment of advanced pancreatic cancer, the prognosis remains grim with 5-year overall survival (OS) of approximately 10%. Early detection is key for improving patient outcomes in this lethal disease. Contributing to the difficulty in the diagnosis and management is the anatomic location of the pancreas within the abdomen (retroperitoneal location and being adjacent to hollow viscus, solid organs and major vessels), and suboptimal response to systemic chemotherapy. Multimodality imaging (pancreatic protocol CT and MRI/MRCP) is often used for the diagnosis and staging of pancreatic adenocarcinoma. Interventional endoscopy is a relatively new field, and with Endoscopic techniques becoming more advanced, their role in diagnosis and management of pancreatic cancer is expanding rapidly. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) are the two main modalities used in cases of pancreatic neoplasms. © Chinese Clinical Oncology. |
| Keywords: | cancer chemotherapy; cancer survival; debridement; unclassified drug; review; advanced cancer; pancreas cancer; cancer staging; antineoplastic agent; cancer diagnosis; cancer palliative therapy; treatment indication; cytology; cancer screening; pruritus; brachytherapy; pancreas adenocarcinoma; surgical drainage; pancreatic cancer; preoperative treatment; intestine obstruction; biliary tract drainage; radiofrequency ablation; photodynamic therapy; analgesia; spectroscopy; biological product; cholestasis; biliary drainage; endoscopic retrograde cholangiopancreatography; tumor necrosis factor; stomach obstruction; marker; contrast-enhanced ultrasound; endoscopic ultrasonography; elastography; celiac plexus; cholangitis; endoscopic ultrasound guided fine needle biopsy; necrosectomy; biliary stent; human; confocal laser scanning microscopy; endoscopic ultrasound (eus); early cancer diagnosis; endoscopic retrograde cholangiopancreatography (ercp); fine needle aspiration (fna); interventional endoscopy; fine needle tattoo; duodenal spectroscopy; pancreas juice |
| Journal Title: | Chinese Clinical Oncology |
| Volume: | 6 |
| Issue: | 6 |
| ISSN: | 2304-3865 |
| Publisher: | AME Publishing Company |
| Date Published: | 2017-12-01 |
| Start Page: | 63 |
| Language: | English |
| DOI: | 10.21037/cco.2017.12.02 |
| PROVIDER: | scopus |
| PUBMED: | 29307203 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2018 -- Source: Scopus |
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