Radiobiology and radiotherapy of brain metastases Journal Article
| Authors: | Thiagarajan, A.; Yamada, Y. |
| Article Title: | Radiobiology and radiotherapy of brain metastases |
| Abstract: | Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved systemic therapy options offering better systemic and intracranial disease control and prolongation of survival as a result of these improvements, making side-effects of proposed therapies (e.g. neurocognitive decline from whole brain radiotherapy) an important consideration. In this article, we review the the primary therapeutic approaches to the management of brain metastases, namely, surgery, stereotactic radiosurgery, and whole brain radiation therapy and the primary factors dictating choice. © 2017, Springer Science+Business Media B.V. |
| Keywords: | cancer surgery; cancer recurrence; multimodality cancer therapy; systemic therapy; cancer patient; neurotoxicity; nuclear magnetic resonance imaging; cancer immunotherapy; risk factor; brain metastasis; erythema; stereotactic radiosurgery; radiation hazard; cancer control; corticosteroid; mental deterioration; dry skin; brain surgery; radiation dermatitis; brain edema; desquamation; brain metastases; radiobiology; whole brain radiotherapy; stereotactic radiotherapy; memantine; corticosteroid therapy; srs; cancer prognosis; human; article; wbrt |
| Journal Title: | Clinical and Experimental Metastasis |
| Volume: | 34 |
| Issue: | 6-7 |
| ISSN: | 0262-0898 |
| Publisher: | Springer |
| Date Published: | 2017-10-01 |
| Start Page: | 411 |
| End Page: | 419 |
| Language: | English |
| DOI: | 10.1007/s10585-017-9865-7 |
| PROVIDER: | scopus |
| PUBMED: | 29139010 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
