Current Management of Metastatic Brain Disease Journal Article
| Authors: | Ranjan, T.; Abrey, L. E. |
| Article Title: | Current Management of Metastatic Brain Disease |
| Abstract: | Brain metastases are the most common intracranial tumor in adults. The incidence of metastases is thought to be rising due to better detection and treatment of systemic malignancy. More widespread use and improved quality of MRI may lead to early detection of brain metastases. Available evidence suggests that survival is longer and quality of life improved if brain metastases are treated aggressively. This article reviews current therapeutic management used for brain metastases. To select the appropriate therapy, the physician must consider the extent of the systemic disease, primary histology, and patient age and performance status, as well as the number, size, and location of the brain metastases. Available treatment options include whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), surgery, and chemotherapy. Multidisciplinary approaches such as the combination of WBRT with SRS or surgery have shown superior results in terms of survival time, neurocognitive function, and quality of life. The utility and optimal use of chemotherapy and radiosensitizing agents is less clear. It is hoped that further advances and multidisciplinary approaches currently under study will result in improved patient outcomes. © 2009 The American Society for Experimental NeuroTherapeutics, Inc. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; prednisone; thalidomide; clinical trial; cancer localization; cisplatin; doxorubicin; fluorouracil; alpha interferon; gemcitabine; paclitaxel; cancer radiotherapy; methotrexate; temozolomide; drug megadose; nuclear magnetic resonance imaging; brain neoplasms; cancer diagnosis; carboplatin; edema; melanoma; quality of life; controlled clinical trial; breast cancer; etoposide; lung non small cell cancer; randomized controlled trial; radiotherapy; cyclophosphamide; vincristine; practice guideline; ifosfamide; vinblastine; docetaxel; irinotecan; brain; celecoxib; radiosurgery; cancer size; gefitinib; brain metastasis; neoplasm metastasis; misonidazole; corticosteroid; drug therapy; navelbine; drug dose regimen; metronidazole; gadolinium texaphyrin; broxuridine; brain metastases; brain metastasis chemotherapy; brain metastasis radiotherapy; brain neoplasm; metastatic brain tumor; efaproxiral; interleukin 2 derivative; lonidamine; stereotaxic surgery; neurosurgical procedures |
| Journal Title: | Neurotherapeutics |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1933-7213 |
| Publisher: | The American Society for Experimental Neurotherapeutics, Inc |
| Date Published: | 2009-07-01 |
| Start Page: | 598 |
| End Page: | 603 |
| Language: | English |
| DOI: | 10.1016/j.nurt.2009.04.012 |
| PUBMED: | 19560748 |
| PROVIDER: | scopus |
| PMCID: | PMC5084194 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "Source: Scopus" |
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