Selective nanoparticle targeting of the renal tubules Journal Article

Authors: Williams, R. M.; Shah, J.; Tian, H. S.; Chen, X.; Geissmann, F.; Jaimes, E. A.; Heller, D. A.
Article Title: Selective nanoparticle targeting of the renal tubules
Abstract: Direct targeting to the kidneys is a promising strategy to improve drug therapeutic index for the treatment of kidney diseases. We sought to investigate the renal selectivity and safety of kidney-targeted mesoscale nanoparticle technology. We found that direct intravenous administration of these particles resulted in 26-fold renal selectivity and localized negligibly in the liver or other organs. The nanoparticles targeted the renal proximal tubular epithelial cells, as evidenced by intravital microscopy and ex vivo imaging. Mice treated with the nanoparticles exhibited no negative systemic consequences, immune reaction, liver impairment, or renal impairment. The localization of material selectively to the renal tubules is uncommon, and this work portends the development of renal-targeted drugs for the treatment of kidney diseases. © 2017 American Heart Association, Inc.
Keywords: controlled study; dose response; nonhuman; mouse; animal; metabolism; animals; mice; animal tissue; immune system; confocal microscopy; kidney disease; fluorescent dye; protein; creatinine; urea nitrogen blood level; pathology; dose-response relationship, drug; diagnostic imaging; drug delivery systems; albumin; kidney; tissue distribution; nanoparticles; nanoparticle; fluorescence microscopy; microscopy, fluorescence; ex vivo study; drug delivery system; particle size; fluorescence imaging; intravenous drug administration; drug carriers; pharmacokinetics; kidney cortex; ion; kidney proximal tubule; kidney tubules, proximal; surface charge; urinary excretion; light scattering; kidney tubule; procedures; biomaterials; globulin; kidney diseases; drug effects; administration, intravenous; female; priority journal; article; kidney tissue; photon correlation spectroscopy; renal elimination
Journal Title: Hypertension
Volume: 71
Issue: 1
ISSN: 0194-911X
Publisher: Lippincott Williams & Wilkins  
Date Published: 2018-01-01
Start Page: 87
End Page: 94
Language: English
DOI: 10.1161/hypertensionaha.117.09843
PUBMED: 29133360
PROVIDER: scopus
PMCID: PMC5730475
Notes: Article -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Daniel Alan Heller
    43 Heller
  2. Janki Kalpesh Shah
    12 Shah
  3. Edgar Alberto Jaimes
    23 Jaimes
  4. Helen Tian
    1 Tian
  5. Xi Chen
    1 Chen