Selective nanoparticle targeting of the renal tubules Journal Article
| Authors: | Williams, R. M.; Shah, J.; Tian, H. S.; Chen, X.; Geissmann, F.; Jaimes, E. A.; Heller, D. A. |
| Article Title: | Selective nanoparticle targeting of the renal tubules |
| Abstract: | Direct targeting to the kidneys is a promising strategy to improve drug therapeutic index for the treatment of kidney diseases. We sought to investigate the renal selectivity and safety of kidney-targeted mesoscale nanoparticle technology. We found that direct intravenous administration of these particles resulted in 26-fold renal selectivity and localized negligibly in the liver or other organs. The nanoparticles targeted the renal proximal tubular epithelial cells, as evidenced by intravital microscopy and ex vivo imaging. Mice treated with the nanoparticles exhibited no negative systemic consequences, immune reaction, liver impairment, or renal impairment. The localization of material selectively to the renal tubules is uncommon, and this work portends the development of renal-targeted drugs for the treatment of kidney diseases. © 2017 American Heart Association, Inc. |
| Keywords: | controlled study; dose response; nonhuman; mouse; animal; metabolism; animals; mice; animal tissue; immune system; confocal microscopy; kidney disease; fluorescent dye; protein; creatinine; urea nitrogen blood level; pathology; dose-response relationship, drug; diagnostic imaging; drug delivery systems; albumin; kidney; tissue distribution; nanoparticles; nanoparticle; fluorescence microscopy; microscopy, fluorescence; ex vivo study; drug delivery system; particle size; fluorescence imaging; intravenous drug administration; drug carriers; pharmacokinetics; kidney cortex; ion; kidney proximal tubule; kidney tubules, proximal; surface charge; urinary excretion; light scattering; kidney tubule; procedures; biomaterials; globulin; kidney diseases; drug effects; administration, intravenous; female; priority journal; article; kidney tissue; photon correlation spectroscopy; renal elimination |
| Journal Title: | Hypertension |
| Volume: | 71 |
| Issue: | 1 |
| ISSN: | 0194-911X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2018-01-01 |
| Start Page: | 87 |
| End Page: | 94 |
| Language: | English |
| DOI: | 10.1161/hypertensionaha.117.09843 |
| PUBMED: | 29133360 |
| PROVIDER: | scopus |
| PMCID: | PMC5730475 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work