Mesoscale nanoparticles selectively target the renal proximal tubule epithelium Journal Article


Authors: Williams, R. M.; Shah, J.; Ng, B. D.; Minton, D. R.; Gudas, L. J.; Park, C. Y.; Heller, D. A.
Article Title: Mesoscale nanoparticles selectively target the renal proximal tubule epithelium
Abstract: We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology. (Figure Presented). © 2015 American Chemical Society.
Keywords: medical nanotechnology; nanoparticles; nanomedicine; diseases; synthesis (chemical); nanotechnology; drug delivery; targeted drug delivery; controlled drug delivery; controlled release; cancer; kidney targeting; proximal tubules; renal disease; renal physiology; uptake mechanism
Journal Title: Nano Letters
Volume: 15
Issue: 4
ISSN: 1530-6984
Publisher: American Chemical Society  
Date Published: 2015-04-08
Start Page: 2358
End Page: 2364
Language: English
DOI: 10.1021/nl504610d
PROVIDER: scopus
PUBMED: 25811353
PMCID: PMC4518714
DOI/URL:
Notes: Export Date: 4 May 2015 -- Source: Scopus
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MSK Authors
  1. Christopher Yongchul Park
    90 Park
  2. Daniel Alan Heller
    112 Heller
  3. Brandon David Ng
    6 Ng
  4. Janki Kalpesh Shah
    23 Shah