Mesoscale nanoparticles selectively target the renal proximal tubule epithelium Journal Article
| Authors: | Williams, R. M.; Shah, J.; Ng, B. D.; Minton, D. R.; Gudas, L. J.; Park, C. Y.; Heller, D. A. |
| Article Title: | Mesoscale nanoparticles selectively target the renal proximal tubule epithelium |
| Abstract: | We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology. (Figure Presented). © 2015 American Chemical Society. |
| Keywords: | medical nanotechnology; nanoparticles; nanomedicine; diseases; synthesis (chemical); nanotechnology; drug delivery; targeted drug delivery; controlled drug delivery; controlled release; cancer; kidney targeting; proximal tubules; renal disease; renal physiology; uptake mechanism |
| Journal Title: | Nano Letters |
| Volume: | 15 |
| Issue: | 4 |
| ISSN: | 1530-6984 |
| Publisher: | American Chemical Society |
| Date Published: | 2015-04-08 |
| Start Page: | 2358 |
| End Page: | 2364 |
| Language: | English |
| DOI: | 10.1021/nl504610d |
| PROVIDER: | scopus |
| PUBMED: | 25811353 |
| PMCID: | PMC4518714 |
| DOI/URL: | |
| Notes: | Export Date: 4 May 2015 -- Source: Scopus |
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