CD19 CAR T cells Journal Article


Author: Sadelain, M.
Article Title: CD19 CAR T cells
Abstract: CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF. CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF. © 2017
Keywords: neoplasm; t lymphocyte; antigen recognition; short survey; target cell; genome; cell stimulation; t lymphocyte activation; immunocompetent cell; cd19 antigen; lymphocyte antigen receptor; complementary dna; antigen function; human; priority journal
Journal Title: Cell
Volume: 171
Issue: 7
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2017-12-14
Start Page: 1471
Language: English
DOI: 10.1016/j.cell.2017.12.002
PROVIDER: scopus
PUBMED: 29245005
DOI/URL:
Notes: Short Survey -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Michel W J Sadelain
    452 Sadelain