At the bench: Chimeric antigen receptor (CAR) T cell therapy for the treatment of B cell malignancies Journal Article
| Authors: | Daniyan, A. F. O.; Brentjens, R. J. |
| Article Title: | At the bench: Chimeric antigen receptor (CAR) T cell therapy for the treatment of B cell malignancies |
| Abstract: | The chimeric antigen receptor (CAR) represents the epitome of cellular engineering and is one of the best examples of rational biologic design of a synthetic molecule. The CAR is a single polypeptide with modular domains, consisting of an antibody-derived targeting moiety, fused in line with T cell-derived signaling domains, allowing for T cell activation upon ligand binding. T cells expressing a CAR are able to eradicate selectively antigen-expressing tumor cells in a MHC-independent fashion. CD19, a tumor-associated antigen (TAA) present on normal B cells, as well as most B cell-derived malignancies, was an early target of this technology. Through years of experimental refinement and preclinical optimization, autologously derived CD19-targeting CAR T cells have been successfully, clinically deployed, resulting in dramatic and durable antitumor responses but not without therapy-associated toxicity. As CD19- targeted CAR T cells continue to show clinical success, work at the bench continues to be undertaken to increase further the efficacy of this therapy, while simultaneously minimizing the risk for treatment-related morbidities. In this review, we cover the history and evolution of CAR technology and its adaptation to targeting CD 19. Furthermore, we discuss the future of CAR T cell therapy and the need to ask, as well as answer, critical questions as this treatment modality is being translated to the clinic. © Society for Leukocyte Biology. |
| Keywords: | adoptive immunotherapy; synthetic biology; cd19; cellular engineering |
| Journal Title: | Journal of Leukocyte Biology |
| Volume: | 100 |
| Issue: | 6 |
| ISSN: | 0741-5400 |
| Publisher: | Federation of American Societies for Experimental Biology |
| Date Published: | 2016-12-01 |
| Start Page: | 1255 |
| End Page: | 1264 |
| Language: | English |
| DOI: | 10.1189/jlb.5BT1215-556RR |
| PROVIDER: | scopus |
| PUBMED: | 27789538 |
| PMCID: | PMC6608016 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2017 -- Source: Scopus |
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