Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy Journal Article
| Authors: | Themeli, M.; Kloss, C. C.; Ciriello, G.; Fedorov, V. D.; Perna, F.; Gonen, M.; Sadelain, M. |
| Article Title: | Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy |
| Abstract: | Progress in adoptive T-cell therapy for cancer and infectious diseases is hampered by the lack of readily available, antigen-specific, human T lymphocytes. Pluripotent stem cells could provide an unlimited source of T lymphocytes, but the therapeutic potential of human pluripotent stem cell-derived lymphoid cells generated to date remains uncertain. Here we combine induced pluripotent stem cell (iPSC) and chimeric antigen receptor (CAR) technologies to generate human T cells targeted to CD19, an antigen expressed by malignant B cells, in tissue culture. These iPSC-derived, CAR-expressing T cells display a phenotype resembling that of innate γδ T cells. Similar to CAR-transduced, peripheral blood γδ T cells, the iPSC-derived T cells potently inhibit tumor growth in a xenograft model. This approach of generating therapeutic human T cells 'in the dish' may be useful for cancer immunotherapy and other medical applications. © 2013 Nature America, Inc. All rights reserved. |
| Journal Title: | Nature Biotechnology |
| Volume: | 31 |
| Issue: | 10 |
| ISSN: | 1087-0156 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-10-01 |
| Start Page: | 928 |
| End Page: | 933 |
| Language: | English |
| DOI: | 10.1038/nbt.2678 |
| PROVIDER: | scopus |
| PUBMED: | 23934177 |
| PMCID: | PMC5722218 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 November 2013" - "CODEN: NABIF" - "Source: Scopus" |
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