Modulation of the apoptotic response: Potential for improving the outcome in clinical radiotherapy Journal Article
| Authors: | Haimovitz-Friedman, A.; Kolesnick, R. N.; Fuks, Z. |
| Article Title: | Modulation of the apoptotic response: Potential for improving the outcome in clinical radiotherapy |
| Abstract: | The most prevalent mechanism of cell kill by radiation is mitosis dependent and results from lethal DNA double-strand breaks and failure to maintain normal replication. Apoptosis is believed to represent a minor component of the clinical effects of radiation. Apoptosis is a preprogrammed death pathway that is constitutively expressed in many cells, albeit in an inactive form, regulated by antiapoptotic mechanisms. Data are presented to show that in irradiated cells the balance between proapoptotic and antiapoptotic signaling may determine the apoptotic outcome in vitro and in vivo. This balance can be modulated by pharmacological intervention to produce a more proapoptotic phenotype, increasing apoptotic cell kill by radiation. These studies establish the basic principles of signaling-based apoptosis therapy, designed to overcome the relative resistance to radiation- induced apoptosis and to improve the therapeutic ratio in the treatment of human tumors with fractionated radiation. |
| Keywords: | signal transduction; nonhuman; dna damage; apoptosis; radiotherapy; radiation injury; radiation response; cell membrane; ceramide; etiology; lung injury; basic fibroblast growth factor; human; priority journal; article |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1996-10-01 |
| Start Page: | 273 |
| End Page: | 283 |
| Language: | English |
| DOI: | 10.1016/s1053-4296(96)80023-3 |
| PROVIDER: | scopus |
| PUBMED: | 10717185 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work