The role of chemotherapy in the treatment of adenocarcinoma of the pancreas Journal Article
| Authors: | Fennelly, D.; Kelsen, D. P. |
| Article Title: | The role of chemotherapy in the treatment of adenocarcinoma of the pancreas |
| Abstract: | Adenocarcinoma of the pancreas is a very disappointing disease. By the time of diagnosis, most patients have extensive metastasis, primarily to the liver, peritoneum, and the lymph system. At this point, the disease is usually too advanced to allow resection. Even if resection is performed, the recurrence rate is high. Therefore, there is an urgent need to develop non-surgical therapies. This paper reviews the current role of chemotherapy in pancreatic adenocarcinoma. Various single agent and multiple agent therapies for advanced and locally advanced pancreatic adenocarcinoma are reviewed and discussed. The role of chemotherapy as an adjuvant therapy to surgical resection is also covered in this paper. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; cisplatin; doxorubicin; fluorouracil; advanced cancer; diarrhea; antineoplastic agents; adjuvant therapy; pancreatic neoplasms; chemotherapy; lymph node metastasis; adenocarcinoma; bone marrow suppression; antimetabolites, antineoplastic; mucosa inflammation; ifosfamide; lomustine; liver metastasis; randomized controlled trials; folinic acid; intraarterial drug administration; pancreas adenocarcinoma; mitomycin c; pancreatic adenocarcinoma; antibiotics, antineoplastic; peritoneum metastasis; leucovorin; intravenous drug administration; oral drug administration; streptozocin; mitomycins; humans; human; priority journal; article; non-surgical therapy |
| Journal Title: | Hepato-Gastroenterology |
| Volume: | 43 |
| Issue: | 8 |
| ISSN: | 0172-6390 |
| Publisher: | H.G.E. Update Medical Publishing Ltd. |
| Date Published: | 1996-03-01 |
| Start Page: | 356 |
| End Page: | 362 |
| Language: | English |
| PUBMED: | 8714228 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 22 November 2017 -- Source: Scopus |
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