Cancer evolution: No room for negative selection Journal Article
| Authors: | Bakhoum, S. F.; Landau, D. A. |
| Article Title: | Cancer evolution: No room for negative selection |
| Abstract: | In this issue of Cell, Martincorena et al. and Campbell et al. interrogated the selection dynamics during tumor evolution using large-scale genomics datasets. They found that somatic mutations in cancer are largely neutral, highlighting a near-complete absence of negative selection. Neutral evolution enables tolerance of hypermutation, which defines a surprisingly large fraction of adult cancer. |
| Keywords: | genes; mutations |
| Journal Title: | Cell |
| Volume: | 171 |
| Issue: | 5 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2017-11-16 |
| Start Page: | 987 |
| End Page: | 989 |
| Language: | English |
| ACCESSION: | WOS:000415317000002 |
| DOI: | 10.1016/j.cell.2017.10.039 |
| PROVIDER: | wos |
| PUBMED: | 29149612 |
| Notes: | Editorial Material -- Source: Wos |
