Beyond genomics: Multidimensional analysis of cancer therapy resistance Journal Article
| Authors: | Philip, M.; Schietinger, A. |
| Article Title: | Beyond genomics: Multidimensional analysis of cancer therapy resistance |
| Abstract: | Cancer resistance to therapy occurs through a selection process generally thought to be driven by mutations. In a recent study, Hugo et al. use multidimensional analysis of the dynamic genetic, transcriptional, epigenetic, and immune landscape alterations in baseline and MAPK inhibitor-resistant melanoma tumors, demonstrating a role for 'non-genomic' drivers in cancer evolution. © 2015. |
| Keywords: | gene mutation; nonhuman; genetic analysis; cd8+ t lymphocyte; cancer immunotherapy; melanoma; gene expression; mitogen activated protein kinase inhibitor; epidermal growth factor receptor; protein tyrosine kinase; cancer therapy; dna methylation; cancer resistance; antigen presentation; immune response; transcription regulation; epigenetics; genomics; short survey; down regulation; upregulation; lymphocytic infiltration; cytotoxic t lymphocyte antigen 4; macrophage; fibroblast growth factor receptor 2; lymphoid enhancer factor 1; cd163 antigen; programmed death 1 receptor; tumor microenvironment; b raf kinase inhibitor; monocyte chemotactic protein 2; human; oncogene c fos; wnt11 protein |
| Journal Title: | Trends in Immunology |
| Volume: | 36 |
| Issue: | 11 |
| ISSN: | 1471-4906 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-11-01 |
| Start Page: | 665 |
| End Page: | 667 |
| Language: | English |
| DOI: | 10.1016/j.it.2015.09.003 |
| PROVIDER: | scopus |
| PUBMED: | 26440701 |
| PMCID: | PMC5104493 |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
