Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: A population-based study Journal Article


Authors: Thordardottir, M.; Lindqvist, E. K.; Lund, S. H.; Costello, R.; Burton, D.; Korde, N.; Mailankody, S.; Eiriksdottir, G.; Launer, L. J.; Gudnason, V.; Harris, T. B.; Landgren, O.; Kristinsson, S. Y.
Article Title: Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: A population-based study
Abstract: All multiple myeloma (MM) cases are preceded by the premalignant state monoclonal gammopathy of undetermined significance (MGUS). Results from previous studies show a positive association between obesity and MM; however, the association between obesity and MGUS is controversial. The aims were to determine (1) if obesity is associated with an increased risk of MGUS and light-chain MGUS (LC-MGUS) and (2) whether obesity is associated with a higher risk of progression to MM and other lymphoproliferative (LP) diseases. Data from the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (N 5 5764) were used. We performed serum protein electrophoresis and serum free light-chain assay on all subjects to identify MGUS and LC-MGUS cases. We included 11 different measures on current and previous obesity in our analysis. Logistic regression and Cox proportional-hazard regression were used to analyze the associations. A total of 300 (5.2%) MGUS and 275 (4.8%) LC-MGUS cases were identified. During a median follow-up of 8 years, 18 had progressed to MM and 11 to other LP diseases. We found no association between the 11 obesity markers and MGUS or LC-MGUS (odds ratios 0.81 to 1.15 for all 11 variables in both conditions). Interestingly, we found that high midlife body mass index increased risk of progression toMMand other LP diseases (hazard ratio, 2.66; 95% confidence interval, 1.17-6.05). To conclude, obesity was not associated with MGUS. However, we found overweight/obesity to be a risk factor for progression from MGUS to MM and other LP diseases, suggesting that obesity plays a role in the transformation of MGUS to MM.
Keywords: mortality; prevalence; long-term; body-mass index; united-states; cohort; working group; pooled analysis; cancer; significance mgus
Journal Title: Blood Advances
Volume: 1
Issue: 24
ISSN: 2473-9529
Publisher: American Society of Hematology  
Date Published: 2017-11-14
Start Page: 2186
End Page: 2192
Language: English
ACCESSION: WOS:000415198300009
DOI: 10.1182/bloodadvances.2017007609
PROVIDER: wos
PMCID: PMC5737120
PUBMED: 29296866
Notes: Article -- Source: Wos
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MSK Authors
  1. Carl Ola Landgren
    198 Landgren
  2. Neha Sanat Korde
    64 Korde