Control of carbon nanotube solvatochromic response to chemotherapeutic agents Journal Article

Authors: Harvey, J. D.; Baker, H. A.; Mercer, E.; Budhathoki-Uprety, J.; Heller, D. A.
Article Title: Control of carbon nanotube solvatochromic response to chemotherapeutic agents
Abstract: Alkylating agents such as cisplatin play an essential role in chemotherapy regimens, but initial and acquired resistance in many cancer types often dampen therapeutic response. The poor understanding of the mechanisms of resistance highlight the need for quantitative measurements of alkylating agent distribution at both the tissue and subcellular levels. Sensors for use in live animals and cells would allow for more effective study of drug action and resistance. Toward this end, single-walled carbon nanotubes suspended with single-stranded DNA have suitable optical properties for in vivo sensors, such as near-infrared emission and sensitivity to the local environment via solvatochromic responses. Currently, solvatochromic changes of such sensors have been limited by the chemical nature of the analyte, making it impossible to control the direction of energy emission changes. Here, we describe a new approach to control the direction and magnitude of solvatochromic responses of carbon nanotubes. We found that the alkylation of DNA on the nanotube surface can result in small changes in DNA conformation that allow the adsorption of amphiphiles to produce large differences (>14 nm) in response to different drugs. The technique surprisingly revealed differences among drugs upon alkylation. The ability to control carbon nanotube solvatochromism as desired may potentially expand the application of nanotube-based optical sensors for new classes of analytes. © 2017 American Chemical Society.
Keywords: chemotherapy; chemical analysis; fluorescence; dna; alkylation; optical properties; mutagens; infrared devices; carbon nanotubes; acquired resistance; chemotherapeutic agents; nanotubes; single-walled carbon nanotubes (swcn); photoluminescence; nanosensor; nanosensors; single-stranded dna; antineoplastic; near-infrared emissions; yarn; cis-diammineplatinum(ii) dichloride; mustard agent; mechanisms of resistances; quantitative measurement
Journal Title: ACS Applied Materials & Interfaces
Volume: 9
Issue: 43
ISSN: 1944-8244
Publisher: American Chemical Society  
Date Published: 2017-11-01
Start Page: 37947
End Page: 37953
Language: English
DOI: 10.1021/acsami.7b12015
PROVIDER: scopus
PUBMED: 29048868
Notes: Article -- Export Date: 4 December 2017 -- Source: Scopus
Citation Impact
MSK Authors
  1. Daniel Alan Heller
    73 Heller
  2. Jackson D Harvey
    13 Harvey
  3. Hanan Baker
    6 Baker