How Schwann cells facilitate cancer progression in nerves Journal Article
| Authors: | Deborde, S.; Wong, R. J. |
| Article Title: | How Schwann cells facilitate cancer progression in nerves |
| Abstract: | Recent studies have demonstrated a critical role for nerves in enabling tumor progression. The association of nerves with cancer cells is well established for a variety of malignant tumors, including pancreatic, prostate and the head and neck cancers. This association is often correlated with poor prognosis. A strong partnership between cancer cells and nerve cells leads to both cancer progression and expansion of the nerve network. This relationship is supported by molecular pathways related to nerve growth and repair. Peripheral nerves form complex tumor microenvironments, which are made of several cell types including Schwann cells. Recent studies have revealed that Schwann cells enable cancer progression by adopting a de-differentiated phenotype, similar to the Schwann cell response to nerve trauma. A detailed understanding of the molecular and cellular mechanisms involved in the regulation of cancer progression by the nerves is essential to design strategies to inhibit tumor progression. © 2017, Springer International Publishing AG. |
| Keywords: | protein expression; disease course; review; cancer growth; nonhuman; neoplasm; neoplasms; protein analysis; animal; animals; cell function; disease association; glial fibrillary acidic protein; pathology; physiology; carcinogenesis; cancer inhibition; disease progression; brain derived neurotrophic factor; nerve fiber; cancer cell; nerve cell adhesion molecule; cell migration; schwann cell; mucin 1; peripheral nerves; protein family; nerve function; cell interaction; invasion; peripheral nerve; migration; chemokine receptor ccr2; perineural invasion; monocyte chemotactic protein 1; brain derived neurotrophic factor receptor; nerve; neurotrophic factor; tumor microenvironment; cell dedifferentiation; schwann cells; epithelial mesenchymal transition; neurotransmission; tumor invasion; protein tyrosine kinase a; neurotrophin 3 receptor; neurotrophin receptor p75; nerve growth factor; chemokine receptor cx3cr1; neurotrophin 3; cancer prognosis; ephrin a1; ephrin a2; semaphorin; myelin associated glycoprotein; cancer; humans; human; fractalkine; slit2 protein |
| Journal Title: | Cellular and Molecular Life Sciences |
| Volume: | 74 |
| Issue: | 24 |
| ISSN: | 1420-682X |
| Publisher: | Springer |
| Date Published: | 2017-12-01 |
| Start Page: | 4405 |
| End Page: | 4420 |
| Language: | English |
| DOI: | 10.1007/s00018-017-2578-x |
| PUBMED: | 28631007 |
| PROVIDER: | scopus |
| PMCID: | PMC5665723 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2017 -- Source: Scopus |
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