Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: Expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1 Journal Article
| Authors: | Eguchi, T.; Kadota, K.; Mayor, M.; Zauderer, M. G.; Rimner, A.; Rusch, V. W.; Travis, W. D.; Sadelain, M.; Adusumilli, P. S. |
| Article Title: | Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: Expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1 |
| Abstract: | Background: To develop cancer antigen-targeted immunotherapeutic strategies for malignant pleural mesothelioma (MPM), we investigated the individual and coexpressions of the cancer-associated antigens mesothelin (MSLN), cancer antigen 125 (CA125), and Wilms tumor 1 (WT1) in both epithelioid and non-epithelioid MPM. Methods: All available hematoxylin and eosin-stained slides from patients who were diagnosed with MPM (1989-2010) were reviewed. We constructed tissue microarrays from 283 patients (epithelioid = 234; non-epithelioid = 49). Intensity and distribution for each antigen were assessed by immunohistochemistry. Results: Positive expression of MSLN, CA125, and WT1 were demonstrated in 93%, 75%, and 97% of epithelioid MPM cases, and 57%, 33%, and 98% of nonepithelioid MPM cases, respectively. Triple- and double-positive antigen coexpressions were demonstrated in 72% and 23% of epithelioid MPM cases and 29% and 33% of non-epithelioid MPM cases, respectively. Complete absence of expression for all three antigens was demonstrated in < 2% of MPM cases. More than two-thirds of MPM cases had ≥50% distribution of MSLN-positive cells and, among the remaining third, half had ≥50% distribution of WT1-positive cells. CA125/MSLN coexpression was observed in more than two-thirds of epithelioid MPM cases and one-third of nonepithelioid MPM cases. Conclusion: A limited number of cancer-associated antigens can target almost all MPM tumors for immunotherapy. © Eguchi et al. |
| Keywords: | mesothelioma; chimeric antigen receptor; ca125; wt1; mesothelin |
| Journal Title: | Oncotarget |
| Volume: | 8 |
| Issue: | 44 |
| ISSN: | 1949-2553 |
| Publisher: | Impact Journals |
| Date Published: | 2017-09-29 |
| Start Page: | 77872 |
| End Page: | 77882 |
| Language: | English |
| DOI: | 10.18632/oncotarget.20845 |
| PROVIDER: | scopus |
| PMCID: | PMC5652821 |
| PUBMED: | 29100432 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2017 -- Source: Scopus |
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