Malignant pleural mesothelioma: Are there imaging characteristics associated with different histologic subtypes on computed tomography? Journal Article
| Authors: | Escalon, J. G.; Harrington, K. A.; Plodkowski, A. J.; Zheng, J.; Capanu, M.; Zauderer, M. G.; Rusch, V. W.; Ginsberg, M. S. |
| Article Title: | Malignant pleural mesothelioma: Are there imaging characteristics associated with different histologic subtypes on computed tomography? |
| Abstract: | Objectives Determine imaging characteristics specific to epithelioid (eMPM), sarcomatoid (sMPM), and biphasic (bMPM) subtypes of malignant pleural mesothelioma (MPM) on computed tomography. Methods Preoperative computed tomography scans of patients with MPM were retrospectively assessed for numerous features including primary affected side, volume loss, pleural thickness, pleural calcifications, pleural effusion, and lymphadenopathy. Results One hundred twenty-five patients with MPM were included. Histologic subdivision was 97 eMPM (77%), 17 bMPM (14%), and 11 sMPM (9%). Nonepithelioid MPM (bMPM and sMPM) was more likely than eMPM to have calcified pleural plaques (P = 0.035). Analyzed separately, bMPM and sMPM each demonstrated calcified plaques more frequently than eMPM, and sMPM more often had internal mammary nodes; however, P values did not reach significance (P = 0.075 and 0.071, respectively). Conclusions Calcified plaques are significantly more common in nonepithelioid subtypes compared with eMPM. Given the different prognoses and management of MPM subtypes, accurate noninvasive subtype classification is clinically vital. © 2018 Wolters Kluwer Health, Inc. |
| Keywords: | aged; retrospective studies; major clinical study; histopathology; preoperative evaluation; computer assisted tomography; image analysis; lung resection; thoracotomy; lung neoplasms; tomography, x-ray computed; diagnostic imaging; retrospective study; histology; lung tumor; pleura mesothelioma; mesothelioma; pleura effusion; pleura tumor; sarcomatoid; pleurectomy; lobectomy; radiodiagnosis; pleura; lymphadenopathy; pleural neoplasms; video assisted thoracoscopic surgery; computed tomography; multidetector computed tomography; pleura thickening; epithelioid; pleura plaque; wedge resection; procedures; humans; human; male; female; priority journal; article; x-ray computed tomography; biphasic; biphasic pleura mesothelioma; epithelioid pleura mesothelioma; sarcomatoid pleura mesothelioma |
| Journal Title: | Journal of Computer Assisted Tomography |
| Volume: | 42 |
| Issue: | 4 |
| ISSN: | 0363-8715 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2018-07-01 |
| Start Page: | 601 |
| End Page: | 606 |
| Language: | English |
| DOI: | 10.1097/rct.0000000000000727 |
| PUBMED: | 29613986 |
| PROVIDER: | scopus |
| PMCID: | PMC6053321 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 September 2018 -- Source: Scopus |
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