Specific binding of liposomal nanoparticles through inverse electron-demand Diels–Alder click chemistry Journal Article
| Authors: | Brand, C.; Iacono, P.; Pérez-Medina, C.; Mulder, W. J. M.; Kircher, M. F.; Reiner, T. |
| Article Title: | Specific binding of liposomal nanoparticles through inverse electron-demand Diels–Alder click chemistry |
| Abstract: | Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels–Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized 89Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, which were validated on a tetrazine-appended polydopamine-coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of 89Zr-TCO–liposomal nanoparticles (89Zr-TCO-LNP) to be immobilized on the tetrazine surface to the control suspensions of non-TCO functionalized 89Zr-liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non-targeted tissues by specific removal of long-circulating liposomal radiopharmaceuticals from the blood pool. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | liposomes; click chemistry; 89zr; tetrazine; trans-cyclooctene; cocrmo alloys |
| Journal Title: | ChemistryOpen |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 2191-1363 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2017-10-01 |
| Start Page: | 615 |
| End Page: | 619 |
| Language: | English |
| DOI: | 10.1002/open.201700105 |
| PROVIDER: | scopus |
| PMCID: | PMC5641912 |
| PUBMED: | 29046855 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2017 -- Source: Scopus |
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