Changes in peripheral blood T-cell balance after percutaneous tumor ablation Journal Article
| Authors: | Takaki, H.; Imai, N.; Thomas, C. T.; Yamakado, K.; Yarmohammadi, H.; Ziv, E.; Srimathveeravalli, G.; Sofocleous, C. T.; Solomon, S. B.; Erinjeri, J. P. |
| Article Title: | Changes in peripheral blood T-cell balance after percutaneous tumor ablation |
| Abstract: | Purpose: To evaluate the changes in T-cell balance in peripheral blood following percutaneous tumor ablation. Material and methods: Patients underwent thermal ablation including radiofrequency (n = 9) and microwave ablation (n = 5), or cryoablation (n = 5). Target tumors were located in the lung (n = 7), soft tissue (n = 5), liver (n = 4), and bone (n = 3). Patient peripheral blood samples were collected before and within 14 days after ablation. Peripheral blood populations of cytotoxic T-cells (CTL), type-1 (Th1) and type-2 helper T-cells (Th2), and regulatory T-cells (Treg) were measured using flow cytometry. Changes in CTL/Treg and Th1/Th2 ratios before and after ablation therapy were compared using paired t-tests. Results: Peripheral blood CTL population (27.5 ± 2.1% to 30.2 ± 2.5%, p <.03) and CTL/Treg ratios (18.8 ± 3.7% to 21.6 ± 3.6%, p <.05) increased significantly after ablation. Although a significant increase in CTL/Treg ratios was found after heat-based ablation (18.0 ± 4.4% to 21.6 ± 4.7%, p <.02), it remained unchanged after cryoablation (21.0 ± 7.0% to 21.5 ± 4.3%, p =.92). Th1/Th2 ratio (13.7 ± 3.0% to 17.2 ± 3.5%, p =.12) remained unchanged after ablation. Conclusion: Ablation therapy alters the T-cell balance by increasing the systemic CTL/Treg, ratio. Heat-based ablation might be a more effective approach than cryoablation to enhance systemic anti-tumor immunity. © 2017 Society of Medical Innovation and Technology. |
| Keywords: | cryoablation; radiofrequency ablation; lymphocyte; t-cell; microwave ablation |
| Journal Title: | Minimally Invasive Therapy and Allied Technologies |
| Volume: | 26 |
| Issue: | 6 |
| ISSN: | 1364-5706 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2017-01-01 |
| Start Page: | 331 |
| End Page: | 337 |
| Language: | English |
| DOI: | 10.1080/13645706.2017.1310737 |
| PROVIDER: | scopus |
| PUBMED: | 28417678 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2017 -- Source: Scopus |
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422Solomon -
200Erinjeri -
244Sofocleous -
131Yarmohammadi -
3Thomas -
111Ziv
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