Peripheral blood regulatory T-cell and type 1 helper T-cell population decrease after hepatic artery embolization Journal Article
| Authors: | Takaki, H.; Imai, N.; Thomas, C. T.; Srimathveeravalli, G.; Covey, A. M.; Getrajdman, G. I.; Brown, K. T.; Solomon, S. B.; Erinjeri, J. P. |
| Article Title: | Peripheral blood regulatory T-cell and type 1 helper T-cell population decrease after hepatic artery embolization |
| Abstract: | Purpose To evaluate changes in T-cell populations in peripheral blood after bland hepatic artery embolization (HAE). Materials and Methods Bland HAE was performed in 12 patients to treat primary (n = 5) or metastatic (n = 7) liver tumors, using microspheres and polyvinyl alcohol (n = 8) or microspheres alone (n = 4). Patient peripheral blood samples were collected within 1 month before HAE, within 1 week after HAE (early period after HAE), and 2–8 weeks after HAE (follow-up period). Peripheral blood populations of cytotoxic T lymphocytes, CD4+ T cells, type 1 helper T cells (Th1) and type 2 helper T cells (Th2), and regulatory T cells (Treg) were evaluated using flow cytometry. Changes in T-cell populations before and after bland HAE were compared using paired t tests. Results Peripheral blood CD4+ T-cell populations decreased significantly in the early period after HAE (44.0% ± 2.2 to 34.4% ± 3.6, P < .01) and in the follow-up period (44.0% ± 2.2 to 36.3% ± 3.0, P < .01). Among the individual CD4+ T-cell subtypes, Treg (2.5% ± 0.3 to 1.7% ± 0.2, P < .02) and Th1 (8.1% ± 1.8 to 5.6% ± 1.6, P < .02) decreased significantly in the early period after HAE only. The presence of extrahepatic disease was associated with decreasing Treg (P < .04). Conclusions After HAE, the peripheral blood T-cell environment is changed with decreases in Treg and Th1. © 2016 SIR |
| Journal Title: | Journal of Vascular and Interventional Radiology |
| Volume: | 27 |
| Issue: | 10 |
| ISSN: | 1051-0443 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2016-10-01 |
| Start Page: | 1561 |
| End Page: | 1568 |
| Language: | English |
| DOI: | 10.1016/j.jvir.2016.01.150 |
| PROVIDER: | scopus |
| PMCID: | PMC5039109 |
| PUBMED: | 27084711 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
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