Effects of roniciclib in preclinical models of anaplastic thyroid cancer Journal Article
| Authors: | Lin, S. F.; Lin, J. D.; Hsueh, C.; Chou, T. C.; Wong, R. J. |
| Article Title: | Effects of roniciclib in preclinical models of anaplastic thyroid cancer |
| Abstract: | Many human cancers have altered cyclin-dependent kinase activity. Inhibition of cyclin-dependent kinases may arrest cell cycle progression and represents an important strategy in the treatment of malignancies. We evaluated the therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor, as a treatment for anaplastic thyroid cancer. Roniciclib inhibited anaplastic thyroid cancer cell proliferation in a dose-dependent manner. Roniciclib activated caspase-3 activity and induced apoptosis. Cell cycle progression was arrested in G2/M phase. In vivo, the growth of anaplastic thyroid cancer xenograft tumors was retarded by roniciclib treatment without evidence of toxicity. These data provide a rationale for further clinical evaluation using roniciclib in the treatment of patients with anaplastic thyroid cancer. |
| Keywords: | cyclin-dependent kinases; management; therapy; cyclin-dependent kinase; prognostic-factors; combination; addiction; anaplastic thyroid cancer; carcinoma cell-lines; cdks; aurora-a kinase; roniciclib |
| Journal Title: | Oncotarget |
| Volume: | 8 |
| Issue: | 40 |
| ISSN: | 1949-2553 |
| Publisher: | Impact Journals |
| Date Published: | 2017-09-15 |
| Start Page: | 67990 |
| End Page: | 68000 |
| Language: | English |
| ACCESSION: | WOS:000410790500098 |
| PROVIDER: | wos |
| PMCID: | PMC5620230 |
| PUBMED: | 28978090 |
| DOI: | 10.18632/oncotarget.19092 |
| Notes: | Article -- Source: Wos |
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