Potent effects of roniciclib alone and with sorafenib against well-differentiated thyroid cancer Journal Article
| Authors: | Lin, S. F.; Lin, J. D.; Hsueh, C.; Chou, T. C.; Wong, R. J. |
| Article Title: | Potent effects of roniciclib alone and with sorafenib against well-differentiated thyroid cancer |
| Abstract: | Activation of cyclin-dependent kinase activity is frequently observed in many human cancers; therefore, cyclin-dependent kinases that promote cell cycle transition and cell proliferation may be potential targets in the treatment of malignancy. The therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor for papillary and follicular thyroid cancer (designated as well-differentiated thyroid cancer), were investigated in this study. Roniciclib inhibited cell proliferation in two papillary and two follicular thyroid cancer cell lines in a dose-dependent manner. Roniciclib activated caspase-3 activity and induced apoptosis. Cell cycle progression was arrested in the G2/M phase. Roniciclib treatment in vivo retarded the growth of two well-differentiated thyroid tumors in xenograft models in a dose-dependent fashion. Furthermore, the combination of roniciclib with sorafenib was more effective than either single treatment in a follicular thyroid cancer xenograft model. Acceptable safety profiles appeared in animals treated with either roniciclib alone or roniciclib and sorafenib combination therapy. These findings support roniciclib as a potential drug for the treatment of patients with well-differentiated thyroid cancer. © 2018 Society for Endocrinology. |
| Keywords: | cyclin-dependent kinase; well-differentiated thyroid cancer; roniciclib |
| Journal Title: | Endocrine-Related Cancer |
| Volume: | 25 |
| Issue: | 10 |
| ISSN: | 1351-0088 |
| Publisher: | Bioscientifica Ltd |
| Date Published: | 2018-10-01 |
| Start Page: | 853 |
| End Page: | 864 |
| Language: | English |
| DOI: | 10.1530/erc-18-0150 |
| PROVIDER: | scopus |
| PUBMED: | 29895526 |
| PMCID: | PMC7475021 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 October 2018 -- Source: Scopus |
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