Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF Journal Article
| Authors: | Quail, D. F.; Olson, O. C.; Bhardwaj, P.; Walsh, L. A.; Akkari, L.; Quick, M. L.; Chen, I. C.; Wendel, N.; Ben-Chetrit, N.; Walker, J.; Holt, P. R.; Dannenberg, A. J.; Joyce, J. A. |
| Article Title: | Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF |
| Abstract: | Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner. Importantly, weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans. Our data indicate that special consideration of the obese patient population is critical for effective management of cancer progression. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. |
| Journal Title: | Nature Cell Biology |
| Volume: | 19 |
| Issue: | 8 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2017-08-01 |
| Start Page: | 974 |
| End Page: | 987 |
| Language: | English |
| DOI: | 10.1038/ncb3578 |
| PROVIDER: | scopus |
| PUBMED: | 28737771 |
| PMCID: | PMC6759922 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 September 2017 -- Source: Scopus |
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