Authors: | Kierdorf, K.; Prinz, M.; Geissmann, F.; Perdiguero, E. G. |
Article Title: | Development and function of tissue resident macrophages in mice |
Abstract: | Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversity of tissue resident macrophages. Here, we want to present the current view on macrophage development and tissue specification and we will discuss differences as well as common patterns between heterogeneous macrophage subpopulations. © 2016 Elsevier Ltd. |
Keywords: | nonhuman; animal experiment; histiocyte; macrophage; histogenesis; mononuclear phagocytes; erythro-myeloid progenitor; tissue specification; pulse labeling models |
Journal Title: | Seminars in Immunology |
Volume: | 27 |
Issue: | 6 |
ISSN: | 1044-5323 |
Publisher: | Academic Press Inc., Elsevier Science |
Date Published: | 2015-12-01 |
Start Page: | 369 |
End Page: | 378 |
Language: | English |
DOI: | 10.1016/j.smim.2016.03.017 |
PROVIDER: | scopus |
PMCID: | PMC4948121 |
PUBMED: | 27036090 |
DOI/URL: | |
Notes: | Review -- Export Date: 1 September 2017 -- Source: Scopus |