The role of cachectin/TNF and other cytokines in sepsis Conference Paper
| Authors: | Zentella, A.; Manogue, K.; Cerami, A. |
| Editors: | Sturk, A.; van Deventer, S. J. H.; Wouter ten Cate, J.; Buller, H. R.; Thijs, L. G.; Levin, J. |
| Title: | The role of cachectin/TNF and other cytokines in sepsis |
| Conference Title: | 3rd International Conference on Endotoxins |
| Abstract: | A traditional view has been that bacterial products, such as endotoxins from gram negative bacteria, have a direct deleterious effect on the host, resulting in fever, hypermetabolism, anorexia, and tissue damage. In recent years, however, it has been shown that endogenous products of the host, secreted by macrophages and other cellular elements of the immune system, act as mediators in activating the metabolic and other physiological changes characteristic of the sepsis syndrome. We will review in depth various aspects of the major, central mediator, i.e., tissue necrosis factor (TNF)/cachectin, and also briefly discuss the interleukins IL-6 and IL-1. |
| Keywords: | genetics; review; pathophysiology; animal; animals; physiology; cytokine; cytokines; tumor necrosis factor alpha; tumor necrosis factor-alpha; sepsis; interleukin 1; interleukin-1; gram-negative bacterial infections; gram negative infection; endotoxin; endotoxins; humans; human |
| Journal Title | Progress in Clinical and Biological Research |
| Volume: | 367 |
| Conference Dates: | 1990 Jun 7-8 |
| Conference Location: | Amsterdam, The Netherlands |
| ISBN: | 0361-7742 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 1991-01-01 |
| Start Page: | 9 |
| End Page: | 24 |
| Language: | English |
| PUBMED: | 1924435 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |