Immunotherapy for malignant pleural mesothelioma: Current status and future directions Journal Article

   


Authors: Dozier, J.; Zheng, H.; Adusumilli, P. S.
Article Title: Immunotherapy for malignant pleural mesothelioma: Current status and future directions
Abstract: Malignant pleural mesothelioma (MPM) has been marked historically by poor prognosis. Current standard of care for this deadly disease results in sub-optimal improvements in overall survival (OS), which has prompted researchers to explore innovative treatment alternatives. Immunotherapy is an emerging therapeutic modality that harnesses the power of the human immune system. In this review, we summarize the different methods of immunotherapy for malignant pleural mesothelioma. Using ClinicalTrials.gov we searched the terms "immunotherapy" and "immune therapy" combined with "pleural mesothelioma". Our search yielded 75 trials, among which 37 trials met our specific criteria. Our search identified immune checkpoint blockade, immunotoxin therapy, anticancer vaccines, oncolytic viral therapy, and adoptive cell therapy as the most common and pertinent methods of immunotherapy currently being assessed in clinical trials. We have reviewed the most up-to-date clinical trials involving immunotherapeutic approaches for the treatment of malignant pleural mesothelioma. In addition to highlighting some of the successes of immunotherapy, we also have identified limitations that must be overcome to improve the efficacy of these therapies. © Translational lung cancer research. All rights reserved.
Keywords: immunotherapy; malignant pleural mesothelioma; thoracic malignancies
Journal Title: Translational Lung Cancer Research
Volume: 6
Issue: 3
ISSN: 2218-6751
Publisher: Translational Lung Cancer Research  
Date Published: 2017-06-01
Start Page: 315
End Page: 324
Language: English
DOI: 10.21037/tlcr.2017.05.02
PROVIDER: scopus
PMCID: PMC5504119
PUBMED: 28713676
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021363348&doi=10.21037%2ftlcr.2017.05.02&partnerID=40&md5=5c86404da1eb5d0406a1aa5e3fae6fa5
Notes: Review -- Export Date: 2 August 2017 -- Source: Scopus
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MSK Authors
  1. Prasad S Adusumilli
    496 Adusumilli
  2. Jordan Michael Dozier
    9 Dozier
  3. Hua Zheng
    4 Zheng
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