Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma Journal Article
| Authors: | Bograd, A. J.; Suzuki, K.; Vertes, E.; Colovos, C.; Morales, E. A.; Sadelain, M.; Adusumilli, P. S. |
| Article Title: | Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma |
| Abstract: | Malignant pleural mesothelioma (MPM) is an aggressive, primary pleural malignancy with poor prognosis, hypothesized to originate from a chronic inflammatory state within the pleura. Similar to what has been observed in other solid tumors (melanoma, ovarian and colorectal cancer), clinical and pre-clinical MPM investigations have correlated anti-tumor immune responses with improved survival. As such, a better understanding of the complex MPM tumor microenvironment is imperative in strategizing successful immunotherapies. Herein, we review the immune responses vital to the development and progression of MPM, as well as assess the role of immunomodulatory therapies, highlighting recent pre-clinical and clinical immunotherapy investigations. © 2011 Springer-Verlag. |
| Keywords: | cancer survival; treatment response; survival rate; unclassified drug; fatigue; pathogenesis; review; cancer growth; drug efficacy; nonhuman; side effect; drug approval; gemcitabine; treatment indication; cd8+ t lymphocyte; cytoreductive surgery; animals; dendritic cell vaccine; interleukin 2; ipilimumab; ticilimumab; cancer immunotherapy; edema; melanoma; infection; anemia; cell infiltration; nausea; neuropathy; vomiting; cyclophosphamide; deep vein thrombosis; gene transfer; viral gene delivery system; abdominal pain; dizziness; drug fever; flushing; injection site reaction; lymphocytopenia; pneumonia; hypoxia; drug induced headache; hypoalbuminemia; hypotension; regulatory t lymphocyte; immune response; immunotherapy; gamma interferon; cancer vaccine; pneumothorax; heart failure; tumor antigens; pleura mesothelioma; mesothelioma; transforming growth factor beta receptor; nausea and vomiting; sepsis; pleura effusion; immunomodulation; skin disease; flu like syndrome; seizure; immunomodulating agent; adenovirus vector; peptide vaccine; cytotoxic t lymphocyte antigen 4; t cell depletion; macrophage; phagocytosis; anaphylaxis; pemetrexed; empyema; beta interferon; congestive heart failure; pleural neoplasms; allergic reaction; immunocompetent cell; drug induced disease; pleurisy; respiratory failure; weight gain; mast cell; clodronic acid; eosinophilia; active immunization; cd40 antigen; immune response to cancer; basiliximab; cd40 ligand monoclonal antibody; mesothelin monoclonal antibody vaccine; monocyte chemotactic protein 1 antibody; recombinant immunotoxin ss1p antibody; wt1 protein vaccine; anasarca; serum sickness; vascular leak syndrome |
| Journal Title: | Cancer Immunology, Immunotherapy |
| Volume: | 60 |
| Issue: | 11 |
| ISSN: | 0340-7004 |
| Publisher: | Springer |
| Date Published: | 2011-11-01 |
| Start Page: | 1509 |
| End Page: | 1527 |
| Language: | English |
| DOI: | 10.1007/s00262-011-1103-6 |
| PROVIDER: | scopus |
| PUBMED: | 21913025 |
| PMCID: | PMC3268654 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: CIIMD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work