Entosis is induced by glucose starvation Journal Article

   


Authors: Hamann, J. C.; Surcel, A.; Chen, R.; Teragawa, C.; Albeck, J. G.; Robinson, D. N.; Overholtzer, M.
Article Title: Entosis is induced by glucose starvation
Abstract: Entosis is a mechanism of cell death that involves neighbor cell ingestion. This process occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill losers. Entosis is driven by a mechanical differential that allows softer cells to eliminate stiffer cells. While this process can be induced by matrix detachment, whether other stressors can activate entosis is unknown. Here, we find that entosis is induced in adherent cells by glucose withdrawal. Glucose withdrawal leads to a bimodal distribution of cells based on their deformability, where stiffer cells appear in a manner requiring the energy-sensing AMP-activated protein kinase (AMPK). We show that loser cells with high levels of AMPK activity are eliminated by winners through entosis, which supports winner cell proliferation under nutrient-deprived conditions. Our findings demonstrate that entosis serves as a cellular response to metabolic stress that enables nutrient recovery through neighbor cell ingestion. © 2017 The Authors
Keywords: controlled study; human cell; cell proliferation; cell death; cell function; enzyme activity; cancer cell; glucose; cell shape; nutrient; phagocytosis; cell adhesion; myosin; tension; glucose metabolism; hydroxymethylglutaryl coenzyme a reductase kinase; ampk; entosis; cannibalism; metabolic stress; cell-in-cell; human; priority journal; article; glucose starvation
Journal Title: Cell Reports
Volume: 20
Issue: 1
ISSN: 2211-1247
Publisher: Cell Press  
Date Published: 2017-07-05
Start Page: 201
End Page: 210
Language: English
DOI: 10.1016/j.celrep.2017.06.037
PROVIDER: scopus
PUBMED: 28683313
PMCID: PMC5559205
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021804139&doi=10.1016%2fj.celrep.2017.06.037&partnerID=40&md5=21c373deead937471fdfc8039186fe30
Notes: Article -- Export Date: 2 August 2017 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Michael H Overholtzer
    81 Overholtzer
  2. Jens C Hamann
    8 Hamann
  3. Ruoyao Chen
    4 Chen
Related MSK Work