Metastasis: From dissemination to organ-specific colonization Journal Article
| Authors: | Nguyen, D. X.; Bos, P. D.; Massague, J. |
| Article Title: | Metastasis: From dissemination to organ-specific colonization |
| Abstract: | Metastasis to distant organs is an ominous feature of most malignant tumours but the natural history of this process varies in different cancers. The cellular origin, intrinsic properties of the tumour, tissue affinities and circulation patterns determine not only the sites of tumour spread, but also the temporal course and severity of metastasis to vital organs. Striking disparities in the natural progression of different cancers raise important questions about the evolution of metastatic traits, the genetic determinants of these properties and the mechanisms that lead to the selection of metastatic cells. © 2009 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | disease course; review; erlotinib; nonhuman; neoplasms; metastasis; breast cancer; cell infiltration; cancer cell; gefitinib; neoplasm metastasis; trastuzumab; tumor gene; host |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-04-01 |
| Start Page: | 274 |
| End Page: | 284 |
| Language: | English |
| DOI: | 10.1038/nrc2622 |
| PUBMED: | 19308067 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 83" - "Export Date: 30 November 2010" - "CODEN: NRCAC" - "Source: Scopus" |
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