Extracellular matrix players in metastatic niches Journal Article
| Authors: | Oskarsson, T.; Massague, J. |
| Article Title: | Extracellular matrix players in metastatic niches |
| Abstract: | Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent reports, including one in a current issue of Nature, point at the extracellular matrix (ECM) proteins periostin and tenascin C (TNC) as key metastatic niche molecules. By enhancing Wnt and Notch signalling in cancer cells, these proteins provide physical as well as signalling support for metastasis-initiating cells. These findings underscore the importance of the ECM environment in cancer and provide potential drug targets against metastasis. © 2012 European Molecular Biology Organization | All Rights Reserved. |
| Keywords: | signal transduction; protein expression; gene mutation; nonhuman; cell viability; cell survival; metastasis; transforming growth factor beta; notch receptor; collagen type 1; extracellular matrix; lung metastasis; cytokine; breast tumor; cancer cell; tumor cell; transgene; fibroblast; cytokine production; polyoma virus; myofibroblast; tumor growth; enzyme release; wnt protein; stem cell niche; fibronectin; tenascin; transcription factor runx2; virus middle t antigen |
| Journal Title: | EMBO Journal |
| Volume: | 31 |
| Issue: | 2 |
| ISSN: | 0261-4189 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2011-12-16 |
| Start Page: | 254 |
| End Page: | 256 |
| Language: | English |
| DOI: | 10.1038/emboj.2011.469 |
| PROVIDER: | scopus |
| PMCID: | PMC3261570 |
| PUBMED: | 22179697 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 2 April 2012" - "CODEN: EMJOD" - "Source: Scopus" |
