Recurrence patterns following irreversible electroporation for hepatic malignancies Journal Article
| Authors: | Langan, R. C.; Goldman, D. A.; D'Angelica, M. I.; DeMatteo, R. P.; Allen, P. J.; Balachandran, V. P.; Jarnagin, W. R.; Kingham, T. P. |
| Article Title: | Recurrence patterns following irreversible electroporation for hepatic malignancies |
| Abstract: | Background: Irreversible electroporation (IRE) has emerged as a novel, safe ablative therapy for peri-vascular lesions. However, there remains a paucity of data on long-term outcomes. Methods: We identified patients who underwent open IRE (1/2011-6/2015) for primary and secondary hepatic malignancies. Local ablation-zone recurrence (LR) was determined by cross-sectional imaging. Cumulative incidence (CumI) of LR was calculated and a competing risks regression assessed factors associated with LR. Results: Forty patients had 77 lesions treated. The majority of lesions were of colorectal origin (74%). Median tumor size was 1.3 cm (range 0.5-6). Most patients (86%) had prior systemic therapy and 29% received systemic therapy following IRE. With a median follow-up of 25.7 months (range 4.5-58.8 months), 10 lesions in 9 patients recurred locally (CumI: 13.4%, 95% CI: 7.8-22.2%). Median estimated time to LR was not reached and no LR occurred after 19 months. Factors significantly associated with LR included ablation zone size (HR 1.58; 95% CI 1.12-2.23; P = 0.0093) and body mass index (HR 1.21 95% CI 1.10-1.34; P = 0.0001). Conclusion: IRE LR rates were low after the treatment of well selected, small tumors. This technique is useful for lesions in anatomic locations precluding resection or thermal ablation. |
| Keywords: | hepatocellular carcinoma; colorectal cancer; tumors; in-vivo; safety; radiofrequency ablation; hepatic metastases; metastatic; efficacy; hepatocellular-carcinoma; liver metastases; microwave ablation; thermal ablation; irreversible electroporation; percutaneous ablation; hepatic malignancy; cancer; liver directed therapy |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 115 |
| Issue: | 6 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2017-05-01 |
| Start Page: | 704 |
| End Page: | 710 |
| Language: | English |
| ACCESSION: | WOS:000403347900008 |
| DOI: | 10.1002/jso.24570 |
| PROVIDER: | wos |
| PUBMED: | 28493544 |
| PMCID: | PMC5647195 |
| Notes: | Article -- Source: Wos |
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637DeMatteo -
501Allen -
903Jarnagin -
777D'Angelica -
609Kingham -
251Balachandran -
158Goldman -
5Langan
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