Design and synthesis of new sulfur-containing hyperbranched polymer and theranostic nanomaterials for bimodal imaging and treatment of cancer Journal Article
| Authors: | Heckert, B.; Banerjee, T.; Sulthana, S.; Naz, S.; Alnasser, R.; Thompson, D.; Normand, G.; Grimm, J.; Manuel Perez, J.; Santra, S. |
| Article Title: | Design and synthesis of new sulfur-containing hyperbranched polymer and theranostic nanomaterials for bimodal imaging and treatment of cancer |
| Abstract: | In this study, we have synthesized a new hyperbranched polyester polymer containing sulfur-pendants (HBPE-S) in the branching points. This HBPE-S polymer is composed of spherical shaped, aliphatic three-dimensional architecture with carboxylic acid groups on the surface. The presence of sulfur pendants in the polymeric cavities demonstrated an important role in the effective encapsulation of Bi-DOTA complexes ([Bi] = 5.21 μM), when compared to the previously reported polymer without sulfur pendants (HBPE, [Bi] = 1.07 × 10-3 μM). Higher X-ray blocking capability and excellent X-ray contrast images were obtained from Bi-DOTA encapsulating HBPE-S polymeric nanoparticles when compared with that of HBPE nanoparticles. In addition, the HBPE-S polymer's spherical structure with amphiphilic cavities allow for the successful encapsulation of antitumor drugs and optical dyes, indicating suitable for delivery of wide-range of theranostic agents for cancer diagnosis and treatment. Therapeutic drug taxol encapsulating, folic acid decorated HBPE-S-Fol nanoparticles showed more than 80% of lung carcinoma cell death within 24 h of incubation. Cell viability and microscopic experiments also confirmed for the targeted delivery, thereby minimizing toxicity to healthy tissues. Taken together, new HBPE-S polymer and multimodal theranostic nanoplatforms were synthesized with enhanced X-ray blocking capability for the effective cancer targeting and treatment monitoring. © 2017 American Chemical Society. |
| Journal Title: | ACS Macro Letters |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 2161-1653 |
| Publisher: | American Chemical Society |
| Date Published: | 2017-03-21 |
| Start Page: | 235 |
| End Page: | 240 |
| Language: | English |
| DOI: | 10.1021/acsmacrolett.7b00008 |
| PROVIDER: | scopus |
| PMCID: | PMC5667566 |
| PUBMED: | 29104818 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
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