Multifunctional MRI/PET nanobeacons derived from the in situ self-assembly of translational polymers and clinical cargo through coalescent intermolecular forces Journal Article

   

Authors:	Kaittanis, C.; Shaffer, T. M.; Bolaender, A.; Appelbaum, Z.; Appelbaum, J.; Chiosis, G.; Grimm, J.
Article Title:	Multifunctional MRI/PET nanobeacons derived from the in situ self-assembly of translational polymers and clinical cargo through coalescent intermolecular forces
Abstract:	Novel multifunctional platforms are needed for oncology in order to assist physicians during surgery and chemotherapy. In the present study, we show that polymeric nanobeacons, consisting of the glucose-based polymer dextran, can be used to guide surgery and improve drug delivery. For imaging, the nanobeacons stably retained the positron emitter 89-zirconium and the MRI contrast agent gadolinium, without the need of a chelator. In addition to using them for PET imaging, the 89Zr-nanobeacons guided the surgical resection of sentinel lymph nodes, utilizing their inherent Cerenkov luminescence. Through weak electrostatic interactions, the nanoparticles carried combinations of chemotherapeutics for the simultaneous inhibition of oncogenic pathways, resulting in enhanced tumor regression. The nanobeacons also allowed monitoring of drug release via MRI, through the quenching of the gadolinium signal by the coloaded drug, making them a new multifunctional theranostic nanotechnology platform for the clinic. © 2015 American Chemical Society.
Keywords:	chemotherapy; gadolinium; magnetic resonance imaging; lymph node; surgery; body fluids; surgical resection; combination therapy; sentinel lymph nodes; polymers; self assembly; chemical bonds; guided surgery; cerenkov-guided surgery; lymph node resection; inter-molecular forces; mri contrast agents; multifunctional platforms
Journal Title:	Nano Letters
Volume:	15
Issue:	12
ISSN:	1530-6984
Publisher:	American Chemical Society
Date Published:	2015-12-09
Start Page:	8032
End Page:	8043
Language:	English
DOI:	10.1021/acs.nanolett.5b03370
PROVIDER:	scopus
PMCID:	PMC4703344
PUBMED:	26540670
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84949603934&partnerID=40&md5=47fb5bd184ac9db43cb6042474b55930
Notes:	Article -- Export Date: 7 January 2016 -- 8032 -- Source: Scopus

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