Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle Journal Article
| Authors: | Thorek, D. L. J.; Ulmert, D.; Diop, N. F. M.; Lupu, M. E.; Doran, M. G.; Huang, R.; Abou, D. S.; Larson, S. M.; Grimm, J. |
| Article Title: | Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle |
| Abstract: | The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with 99m Tc-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, 89 Zr-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that 89 Zr-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging. © 2014 Macmillan Publishers Limited. All rights reserved. |
| Journal Title: | Nature Communications |
| Volume: | 5 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2014-01-20 |
| Start Page: | 3097 |
| Language: | English |
| DOI: | 10.1038/ncomms4097 |
| PROVIDER: | scopus |
| PUBMED: | 24445347 |
| PMCID: | PMC4080716 |
| DOI/URL: | |
| Notes: | Export Date: 3 March 2014 -- Source: Scopus |
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