Patient-derived tumor xenograft: Present and future challenges and applications Book Section
| Authors: | Inghirami, G.; Tinkey, P. T.; de Stanchina, E.; Uthamanthil, R. K. |
| Editors: | Uthamanthil, R.; Tinkey, P.; de Stanchina, E. |
| Article/Chapter Title: | Patient-derived tumor xenograft: Present and future challenges and applications |
| Abstract: | Patient-derived tumor xenografts have suddenly emerged as a highly desirable platform in oncology. Many applications have been explored and many others are on the horizon, all with the main objective of improving molecular and biological discoveries, executing more effective drug screenings, and providing new patient customized therapies. Although impressive results have already been rapidly achieved, many questions remain and newer applications continue to be explored. In this chapter, we review the most pressing issues and proposed possible solutions. Future challenges and innovative applications have been introduced. © 2017 Elsevier Inc. All rights reserved. |
| Keywords: | mice; cell line; animal model; translational medical research; heterografts; patient-derived xenograft; biological specimen banks; personalized cancer therapy |
| Book Title: | Patient Derived Tumor Xenograft Models: Promise, Potential and Practice |
| ISBN: | 978-0-12-804010-2 |
| Publisher: | Academic Press, Elsevier Inc |
| Publication Place: | London, UK |
| Date Published: | 2017-01-01 |
| Start Page: | 429 |
| End Page: | 451 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-804010-2.00027-8 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Section V Chapter 1 -- Export Date: 3 July 2017 -- Source: Scopus |
