Chemotherapy of colorectal cancer: History and new themes Journal Article
| Author: | Bertino, J. R. |
| Article Title: | Chemotherapy of colorectal cancer: History and new themes |
| Abstract: | Since the clinical introduction of 5-fluorouracil (5-FU) in 1958, improvements in the treatment of advanced colorectal cancer have been modest. However, improvements in response rates have been demonstrated when 5-FU is administered in conjunction with leucovorin, and when methotrexate or trimetrexate is administered preceding 5-FU, indicating that higher response rates could be achieved by biomodulating the activity of 5-FU. Thus, significant emphasis has been placed on designing more effective 5-FU-based combination regimens. Novel agents, including the thymidylate synthase inhibitor raltritrexed and the topoisomerase I inhibitor irinotecan, also have demonstrated activity in colorectal cancer. Other new approaches include the administration of oral 5-FU prodrugs. The development of novel agents, new therapeutic approaches, and the refinement of existing agents and regimens in the clinic will likely improve response rates and, ultimately, patient survival. The history, current treatment options, and future opportunities for advances in Chemotherapy for the treatment of colorectal cancer are discussed. |
| Keywords: | cancer chemotherapy; cancer survival; unclassified drug; clinical trial; review; fluorouracil; drug efficacy; nonhuman; methotrexate; dna synthesis; colorectal cancer; animals; antimetabolites, antineoplastic; antineoplastic combined chemotherapy protocols; antineoplastic activity; irinotecan; colorectal neoplasms; history, 20th century; rna; dna; drug mechanism; folinic acid; intraarterial drug administration; thymidine kinase; drug metabolism; thymidylate synthase inhibitor; thymidylate synthase; floxuridine; pemetrexed; thymidine phosphorylase; uridine; thymidine; prodrug; oral drug administration; tegafur; prodrugs; hydrogen; raltitrexed; fluorine; trimetrexate; uracil; nolatrexed; intraperitoneal drug administration; dihydropyrimidine dehydrogenase; methylenetetrahydrofolic acid; humans; human; priority journal; fluorouridine; 5 ethynyluracil; 2 [5 [[(1,2 dihydro 3 methyl 1 oxobenzo[f]quinazolin 9 yl)methyl]amino] 1 oxo 2 isoindolinyl]glutaric acid; plevitrexed |
| Journal Title: | Seminars in Oncology |
| Volume: | 24 |
| Issue: | 5 Suppl. 18 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-10-01 |
| Start Page: | S18-3 |
| End Page: | S18-7 |
| Language: | English |
| PUBMED: | 9420015 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
